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A poor prognosis in human hepatocellular carcinoma is associated with low expression of DPP4 BJMBR
Yu,Hao; Mei,Xiao-Ping; Su,Peng-Fei; Jin,Guang-Zhi; Zhou,Hong-Kun.
This study aimed to explore the prognostic role of dipeptidyl peptidase 4 (DPP4) expression in hepatocellular carcinoma (HCC). DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients. Immunohistochemistry analyses were utilized to examine DPP4 expression characteristics and prognostic values (overall survival (OS) and time to recurrence) of DDP4 in HCC tissues. In addition, a patient-derived xenograft (PDX) model was used to assess the correlation between DPP4 expression and tumor growth in vivo. DPP4 was expressed in low levels in HCC tissues in contrast to paired peritumoral tissues (38 cases were down-regulated in a total of 59 cases, 64.4%. P=0.0202). DPP4 expression was significantly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dipeptidyl peptidase 4; Hepatocellular carcinoma; Immunohistochemistry; X-tile; Overall survival; Patient-derived xenograft.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400609
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